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Article

Suppression of src-induced transformed phenotype by expression of tropomyosin-1.

Oncogene - 18 Mar 1999

Prasad G L, Masuelli L, Raj M H, Harindranath N

Abstract excerpt

Suppression of high M(r) tropomyosins (TMs) is a common feature of transformed cells. Previous work from this laboratory has demonstrated that the isoform 1 of TM, TM1, acts as an anti-oncogene in ras-transformed murine fibroblasts. In this study, we have investigated whether TM1 is a ras-specific suppressor, or a general suppressor protein of the cellular transformation. V-src transformed fibroblasts, which...

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Identifiers

PMID: 10208425
DOI: 10.1038/sj.onc.1202264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Suppression of src-induced transformed phenotype by expression of tropomyosin-1.PMID 10208425Read ↗

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Activated Src abrogates the Myc requirement for the G0/G1 transition but not for the G1/S transition.Semantic proximity Read ↗

Regulation of microfilament organization and anchorage-independent growth by tropomyosin 1.Semantic proximity Read ↗

v-src-induced cell shape changes in rat fibroblasts require new gene transcription and precede loss of focal adhesions.Semantic proximity Read ↗

The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors.Semantic proximity Read ↗

A dominant negative Raf-1 mutant prevents v-Src-induced transformation.Semantic proximity Read ↗

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Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype.Semantic proximity Read ↗

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