Article
Suppression of the transformed phenotype of breast cancer by tropomyosin-1.
Experimental cell research - 10 Sept 2002
Mahadev Kalyankar, Raval Gira, Bharadwaj Shantaram, Willingham Mark C, Lange Ethan M, Vonderhaar Barbara, Salomon David, Prasad G L
Abstract excerpt
Changes in the expression of microfilament-associated proteins, such as tropomyosins (TMs), are commonly found in malignantly transformed cells. Previous work from this laboratory has shown that tropomyosin-1 (TM1) expression is consistently abolished in human breast carcinoma cell lines, suggesting that the loss of TM1 could be a common biochemical event in the transformation of mammary epithelium. To...
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