Article
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.
The New England journal of medicine - 11 Jan 1996
Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Ogura Y, Izumi N, Marumo F, Sato C
Abstract excerpt
BACKGROUND: A region associated with sensitivity to interferon has been identified in the nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) genotype 1b. The region spans amino acid residues 2209 to 2248 (NS5A2209-2248) of HCV-J, a strain of HCV-1b whose complete genomic sequence has been...
Topics
- Amino Acid Sequence
- Base Sequence
- Chronic Disease
- Female
- Hepacivirus
- Hepatitis C
- Humans
- Interferon-alpha
- Male
- Middle Aged
- Molecular Sequence Data
- Multivariate Analysis
- Mutation
- RNA, Viral
- Retrospective Studies