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Article

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats.

Animal models and experimental medicine - 1 Mar 2026

Lepáček Marek, Boďo Pavol, Kaločayová Barbora, Šoltésová Prnová Marta

Abstract excerpt

BACKGROUND: Zucker diabetic fatty (ZDF) rats exhibit significant phenotypic variability despite genetic uniformity, yet a comprehensive characterization of these divergent phenotypes remains limited. METHODS: Male ZDF (fa/fa) rats (4 months, n = 22) and ZDF (fa/+) lean controls (n = 10) were maintained on standard chow for 6 months. Based on metabolic trajectory, ZDF (fa/fa) rats were stratified into three...

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Identifiers

PMID: 41804550
DOI: 10.1002/ame2.70148
PMCID: PMC13176109

Genes

FGF21

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