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Article

Low frequency of germline E-cadherin mutations in familial and nonfamilial gastric cancer

12 Mar 1999

Abstract excerpt

Little is known about the relative contributions of genetic and environmental factors to the development of gastric cancer. Mutations in the cell adhesion molecule E-cadherin are recognized to be associated with the development of undifferentiated, diffuse and invasive gastric cancers. A recent study of two gastric cancer families has shown that germline mutations in the E-cadherin gene can be causative (Guilford...

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PMID: 10206317
DOI: 10.1038/sj.bjc.6690308

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