Article
High incidence of familial gastric cancer in Tuscany, a region in Italy.
Oncology - 1 Jan 2007
Roviello Franco, Corso Giovanni, Pedrazzani Corrado, Marrelli Daniele, De Falco Giulia, Suriano Gianpaolo, Vindigni Carla, Berardi Anna, Garosi Lorenzo, De Stefano Alfonso, Leoncini Lorenzo, Seruca Raquel, Pinto Enrico
Abstract excerpt
OBJECTIVES: Only 1% of diffuse gastric cancers occur in families with autosomal dominant gastric cancer susceptibility. Germline mutations in the E-cadherin gene account for the hereditary diffuse gastric cancer (HDGC) syndrome. We studied a large cohort of gastric cancer patients from Tuscany, a...
Topics
- Adult
- Aged
- Aged, 80 and over
- Cadherins
- Female
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Incidence
- Italy
- Male
- Middle Aged
- Pedigree
- Retrospective Studies
- Stomach Neoplasms