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Article

Germline mutations of the E-cadherin gene in families with inherited invasive lobular breast carcinoma but no diffuse gastric cancer.

Cancer - 15 Jul 2011

Xie Ze Ming, Li Lai Sheng, Laquet Claire, Penault-Llorca Frédérique, Uhrhammer Nancy, Xie Xiao Ming, Bignon Yves Jean

Abstract excerpt

BACKGROUND: Present data are highly suggestive but do not unequivocally prove the cosegregation of germ-line CDH1 mutations with inherited invasive lobular breast cancer (ILBC). METHODS: Two Caucasian families with 6 pathologically confirmed ILBC cases but no diffuse gastric cancer (DGC) were identified in our oncogenetics consultations. Screening for mutations of CDH1, BRCA1, and BRCA2 genes was performed on...

Topics

Breast Neoplasms
Cadherins
Carcinoma, Lobular
Female
Gastrectomy
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Middle Aged
Pedigree
Stomach Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21271559
DOI: 10.1002/cncr.25876

Genes

CDH1
BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21271559-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Germline mutations of the E-cadherin gene in families with inherited invasive lobular breast carcinoma but no diffuse gastric cancer.PMID 21271559Read ↗

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