Comparison of human immunodeficiency virus type 1 (HIV-1) protease mutations in HIV-1 genomes detected in plasma and in peripheral blood mononuclear cells from patients receiving combination drug therapy.

Abstract excerpt

Detections of mutations in the protease gene of human immunodeficiency virus type 1 in plasma and peripheral blood mononuclear cells (PBMC) were sought in two matched populations of 23 individuals receiving combination drug therapy with or without protease inhibitors. In the control group (23 patients not receiving protease inhibitors), no primary resistance mutations were found. In contrast, primary resistance...

Topics

• Acquired Immunodeficiency Syndrome
• Codon
• Drug Therapy, Combination
• Genome, Viral
• HIV Protease
• HIV Protease Inhibitors
• HIV-1
• Humans
• Leukocytes, Mononuclear
• Mutation