Article
HIV-1 Protease and reverse-transcriptase mutations: correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance.
The Journal of infectious diseases - 1 Aug 2005
Rhee Soo-Yon, Fessel W Jeffrey, Zolopa Andrew R, Hurley Leo, Liu Tommy, Taylor Jonathan, Nguyen Dong Phuong, Slome Sally, Klein Daniel, Horberg Michael, Flamm Jason, Follansbee Stephen, Schapiro Jonathan M, Shafer Robert W
Abstract excerpt
Background. It is important, for drug-resistance surveillance, to identify human immunodeficiency virus type 1 (HIV-1) strains that have undergone antiretroviral drug selection.Methods. We compared the prevalence of protease and reverse-transcriptase (RT) mutations in HIV-1 sequences from persons with and without previous treatment with protease inhibitors (PIs), nucleoside RT inhibitors (NRTIs), and...
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