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Article

Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance.

Journal of virology - 1 Nov 2009

Kolli Madhavi, Stawiski Eric, Chappey Colombe, Schiffer Celia A

Abstract excerpt

Drug resistance is an important cause of antiretroviral therapy failure in human immunodeficiency virus (HIV)-infected patients. Mutations in the protease render the virus resistant to protease inhibitors (PIs). Gag cleavage sites also mutate, sometimes correlating with resistance mutations in the protease, but their contribution to resistance has not been systematically analyzed. The present study examines...

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Share to Binding Sites
Share to Drug Resistance, Viral
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to HIV Protease Inhibitors

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Share to Protein Conformation

Source

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Identifiers

PMID: 19706699
DOI: 10.1128/JVI.00628-09
PMCID: PMC2772784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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