Article
Resistance mutations in protease and reverse transcriptase genes of human immunodeficiency virus type 1 isolates from patients with combination antiretroviral therapy failure.
The Journal of infectious diseases - 1 Nov 1998
Young B, Johnson S, Bahktiari M, Shugarts D, Young R K, Allen M, Ramey R R, Kuritzkes D R
Abstract excerpt
High-density oligonucleotide arrays were used to determine the sequence of the protease (PR) and reverse transcriptase (RT) genes of human immunodeficiency virus type 1 isolates from 35 patients in whom combination therapy that included a protease inhibitor had failed. Isolates had a median of three PR mutations (range, none to six). Three isolates had no known resistance mutations in PR. Twelve isolates (34%)...
Topics
- Anti-HIV Agents
- Codon
- Consensus Sequence
- Drug Resistance, Microbial
- Drug Therapy, Combination
- HIV Infections
- HIV Protease
- HIV Reverse Transcriptase
- HIV-1
- Humans