Article
Mutation patterns of the reverse transcriptase and protease genes in human immunodeficiency virus type 1-infected patients undergoing combination therapy: survey of 787 sequences.
Journal of clinical microbiology - 1 Dec 1999
Yahi N, Tamalet C, Tourrès C, Tivoli N, Ariasi F, Volot F, Gastaut J A, Gallais H, Moreau J, Fantini J
Abstract excerpt
The aim of the present study was to evaluate the resistance-associated mutations in 302 human immunodeficiency virus type 1 (HIV-1)-infected patients receiving combination therapy and monitored in Marseille, France, hospitals from January 1997 to June 1998. In the reverse transcriptase (RT) gene, the most frequent mutations were found at codons 215 (53%), 41 (34%), and 67, 70, 184, and 210 (>20%). One deletion...
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