Article
In vivo kinetics of human apolipoprotein A-I variants in rabbits.
European journal of clinical investigation - 1 Mar 1999
Saku K, von Eckardstein A, Zhang B, Liu R, Jimi S, Ou J, Ohta T, Assmann G, Arakawa K
Abstract excerpt
BACKGROUND: Genetic variants of human apolipoprotein (apo) A-I, the major protein component of high-density lipoprotein (HDL), with a single amino acid substitution have been reported, and some of these result in very low plasma HDL-cholesterol (C) levels. Examining the kinetics of radiolabelled apolipoprotein is a straightforward technique for determining its metabolism in vivo. In this study, we investigated...
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