Article
Different VLDL apo B, and HDL apo AI and apo AII metabolism in two heterozygous carriers of unrelated mutations in the lipoprotein lipase gene.
Clinica chimica acta; international journal of clinical chemistry - 1 Jun 2006
Pérez-Méndez Oscar, Duhal Nathalie, Lacroix Brigitte, Bonte Jean-Paul, Fruchart Jean-Charles, Luc Gérald
Abstract excerpt
BACKGROUND: Lipoprotein lipase (LPL) deficiency has been suggested as a cause of low HDL-cholesterol (HDL-C) plasma levels, by a mechanism that involves an enhanced catabolism of HDL apolipoprotein (apo) AI. To verify the role of 2 different LPL gene mutations on HDL metabolism, we studied the in vivo turnover of the apo AI and apo AII in heterozygous carriers of LPL deficiency. METHODS: Apo AI and AII kinetics...
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