Article
In vivo metabolism of a mutant apolipoprotein, apoA-IIowa, associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis.
Journal of lipid research - 1 May 1992
Rader D J, Gregg R E, Meng M S, Schaefer J R, Zech L A, Benson M D, Brewer H B
Abstract excerpt
Apolipoprotein (apo) A-I is the major protein constituent of plasma high density lipoproteins (HDL). A kindred has been identified in which a glycine to arginine mutation at residue 26 in apoA-I is associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis. We isolated the mutant protein, termed apoA-IIowa, from the plasma of an affected subject and studied its in vivo metabolism compared to...
Topics
- Adult
- Amyloidosis
- Apolipoprotein A-I
- Arginine
- Electrophoresis, Gel, Two-Dimensional
- Female
- Glycine
- Humans
- Hypolipoproteinemias
- Immunoblotting
- Lipoproteins, HDL