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Article

Dominant expression of type III hyperlipoproteinemia. Pathophysiological insights derived from the structural and kinetic characteristics of ApoE-1 (Lys146-->Glu).

The Journal of clinical investigation - 1 Aug 1995

Mann W A, Lohse P, Gregg R E, Ronan R, Hoeg J M, Zech L A, Brewer H B

Abstract excerpt

Type III hyperlipoproteinemia is characterized by delayed chylomicron and VLDL remnant catabolism and is associated with homozygosity for the apoE-2 allele. We have identified a kindred in which heterozygosity for an apoE mutant, apoE-1 (Lys146-->Glu), is dominantly associated with the expression...

Topics

Adult
Alleles
Apolipoproteins E
Cells, Cultured
DNA Mutational Analysis
Female
Fibroblasts
Genes, Dominant
Heparin
Humans
Hyperlipoproteinemia Type III
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Point Mutation

Protein Binding

Receptors, LDL

Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 7635945
DOI: 10.1172/JCI118096
PMCID: PMC185299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7635945-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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