Article
In vivo metabolism of a mutant form of apolipoprotein A-I, apo A-IMilano, associated with familial hypoalphalipoproteinemia.
The Journal of clinical investigation - 1 Apr 1993
Roma P, Gregg R E, Meng M S, Ronan R, Zech L A, Franceschini G, Sirtori C R, Brewer H B
Abstract excerpt
Apo A-IMilano is a mutant form of apo A-I in which cysteine is substituted for arginine at amino acid 173. Subjects with apo A-IMilano are characterized by having low levels of plasma HDL cholesterol and apo A-I. To determine the kinetic etiology of the decreased plasma levels of the apo A-I in t...
Topics
- Adult
- Apolipoprotein A-I
- Cholesterol
- Female
- Heterozygote
- Humans
- Hypolipoproteinemias
- Kinetics
- Lipoproteins, HDL
- Male
- Mutation
- Tangier Disease
- Triglycerides