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Article

Metabolism of apolipoproteins AI and AII in subjects carrying similar apoAI mutations, apoAI Milano and apoAI Paris.

Atherosclerosis - 1 Feb 2000

Perez-Mendez O, Bruckert E, Franceschini G, Duhal N, Lacroix B, Bonte J P, Sirtori C, Fruchart J C, Turpin G, Luc G

Abstract excerpt

ApoAI Milano (AI(M)) and apoAI Paris (AI(P)) are mutant forms of apoAI in which cysteine is substituted for arginine at residues 173 and 151 respectively leading to the formation of homodimers and heterodimers with apoAII. Heterozygous subjects with these mutants are characterized by low levels of plasma HDL cholesterol and apoAI. The present study analyzed the metabolism of the different complexes of apoAI in...

Topics

Adult
Apolipoprotein A-I
Apolipoprotein A-II
Dimerization
Heterozygote
Humans
Kinetics
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10657568
DOI: 10.1016/s0021-9150(99)00279-8

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