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Article

Carboxyl-terminal Domain Truncation Alters Apolipoprotein A-I in Vivo Catabolism

1 Mar 1995

Abstract excerpt

Apolipoprotein A-I (apoA-I), the major protein of high density lipoproteins, facilitates reverse cholesterol transport from peripheral tissue to liver. To determine the structural motifs important for modulating the in vivo catabolism of human apoA-I (h-apoA-I), we generated carboxyl-terminal truncation mutants at residues 201 (apoA-I201), 217 (apoA-I217), and 226 (apoA-I226) by site-directed mutagenesis. ApoA-I...

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Identifiers

PMID: 7890663
DOI: 10.1074/jbc.270.10.5469

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