Article
Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2002
Huang Se-Te J, Cidlowski John A
Abstract excerpt
Glucocorticoids are known to induce apoptosis in lymphoid cells, and Bcl-2 overexpression can block the apoptosis-inducing action of glucocorticoids. Since phosphorylation of Bcl-2 is implicated in regulating Bcl-2 function, we considered the role of Bcl-2 phosphorylation in protecting lymphoid cells from glucocorticoid-induced cell death. Five stably transfected cell lines of WEHI 7.1 cells expressing either...
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