Article

The role of inflammation in a humanized mouse model of transthyretin cardiac amyloidosis

2024-12-25

Abstract excerpt

<h4>Background</h4> Systemic amyloidosis represents a group of protein-misfolding diseases that confer significant morbidity and mortality for millions of patients worldwide. Transthyretin cardiac amyloidosis (ATTR) is a particularly devastating amyloid disease that affects middle-aged and elderly individuals and leads to cardiomyopathy (ATTR-CM), which has a median survival of 2.5 to 3.5 years [1, 2]. ATTR-CM ca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7ecb5eba-e056-5d5d-9e1e-cb9efd458a83
DOI: 10.1101/2024.12.24.629308

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The role of inflammation in a humanized mouse model of transthyretin cardiac amyloidosisDOI 10.1101/2024.12.24.629308Read

In vitro and in vivo disease models of cardiac amyloidosis: progress, pitfalls, and potential.Semantic proximity Read

Cardiac amyloidosis: An update on pathophysiology, diagnosis, and treatment.Semantic proximity Read

Cardiac Amyloidosis: Evolving Diagnosis and Management: A Scientific Statement From the American Heart Association.Semantic proximity Read

Transthyretin amyloidosis: an under-recognized neuropathy and cardiomyopathySemantic proximity Read

Diagnosis and Treatment of Transthyretin Cardiac Amyloidosis. Progress and Hope.Semantic proximity Read

Amyloid Cardiomyopathy.Semantic proximity Read

Prospective evaluation of the morbidity and mortality of wild-type and V122I mutant transthyretin amyloid cardiomyopathy: the Transthyretin Amyloidosis Cardiac Study (TRACS).Semantic proximity Read

Not So Rare After All: Rethinking Hereditary Transthyretin AmyloidosisSemantic proximity Read

Amyloid and the Heart.Semantic proximity Read

The importance of pre-clinical studies in animal models of TTR amyloidosis for the discovery of novel patient disease biomarkers.Semantic proximity Read

Pathophysiology and treatment of cardiac amyloidosis.Semantic proximity Read

Exploring the MicroRNA Landscape in Cardiac Amyloidosis: Molecular Insights and Clinical ApplicationsSemantic proximity Read