Article
Characterization of Prophet of Pit-1 gene expression in normal pituitary and pituitary adenomas in humans.
The Journal of clinical endocrinology and metabolism - 1 Apr 1999
Nakamura Y, Usui T, Mizuta H, Murabe H, Muro S, Suda M, Tanaka K, Tanaka I, Shimatsu A, Nakao K
Abstract excerpt
Prophet of Pit-1 (Prop-1), which is a paired-like homeodomain transcription factor, is capable of binding to sites in an early enhancer of the Pit-1 gene and regulating its expression. According to a previous report, Prop-1 messenger RNA (mRNA) is expressed in the developing pituitary gland before Pit-1 mRNA expression and maximum expression are observed at e 12.0. After e 14.5, Prop-1 mRNA expression rapidly...
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