Article
Differential conservation of transcriptional domains of mammalian Prophet of Pit-1 proteins revealed by structural studies of the bovine gene and comparative functional analysis of the protein.
Gene - 29 May 2002
Showalter Aaron D, Smith Timothy P L, Bennett Gary L, Sloop Kyle W, Whitsett Julie A, Rhodes Simon J
Abstract excerpt
The Prophet of Pit-1 (PROP1) gene encodes a paired class homeodomain transcription factor that is exclusively expressed in the developing mammalian pituitary gland. PROP1 function is essential for anterior pituitary organogenesis, and heritable mutations in the gene are associated with combined pituitary hormone deficiency in human patients and animals. By cloning the bovine PROP1 gene and by comparative...
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