Article
Human Prop-1: cloning, mapping, genomic structure. Mutations in familial combined pituitary hormone deficiency.
FEBS letters - 23 Oct 1998
Duquesnoy P, Roy A, Dastot F, Ghali I, Teinturier C, Netchine I, Cacheux V, Hafez M, Salah N, Chaussain J L, Goossens M, Bougnères P, Amselem S
Abstract excerpt
Prop-1 is a newly isolated pituitary-specific paired-like homeodomain transcription factor whose cDNA sequence is well known in mouse. To study its involvement in human combined pituitary hormone deficiency (CPHD), we have isolated the human cDNA ortholog and determined the exon/intron organization and chromosomal localization of the human gene. A Prop-1 defect was characterized in three CPHD families. One...
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