Article

"Hot Spot" in the PROP1 Gene Responsible for Combined Pituitary Hormone Deficiency

1999-05-01

Abstract excerpt

As pituitary function depends on the integrity of the hypothalamic-pituitary axis, any defect in the development and organogenesis of this gland may account for a form of combined pituitary hormone deficiency (CPHD). Although pit-1 was 1 of the first factors identified as a cause of CPHD in mice, many other homeodomain and transcription factors have been characterized as being involved in different developmental s...

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Identifiers and source

Literature Corpus work: d9082775-a6be-5ed6-b4a3-479fbc38e70a
DOI: 10.1210/jc.84.5.1645

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