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Article

Phosphorylation of human MAD1 by the BUB1 kinase in vitro.

Biochemical and biophysical research communications - 13 Apr 1999

Seeley T W, Wang L, Zhen J Y

Abstract excerpt

The BUB/MAD signaling pathway monitors attachment of chromosomes to spindle poles in mitotic cells. Mutations of the human BUB1 locus were identified in cancer cells exhibiting an unstable chromosomal complement. We report that the human BUB3 gene maps to a site on chromosome 10 subject to frequent modification in cancers. Thus, defects in BUB/MAD signaling may contribute to genetic instability and to cancer...

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Source

Identifiers

PMID: 10198256
DOI: 10.1006/bbrc.1999.0514

Genes

BUB1
BUB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation of human MAD1 by the BUB1 kinase in vitro.PMID 10198256Read ↗

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The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.Semantic proximity Read ↗

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