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Article

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.

Oncogene - 25 Sept 2006

Gudmundsdottir K, Ashworth A

Abstract excerpt

The BRCA1 and BRCA2 proteins are important in maintaining genomic stability by promoting efficient and precise repair of double-strand breaks. The main role of BRCA2 appears to involve regulating the function of RAD51 in the repair by homologous recombination. BRCA1 has a broader role upstream of BRCA2, participating in various cellular processes in response to DNA damage. The DNA repair defect associated with...

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Source

Identifiers

PMID: 16998501
DOI: 10.1038/sj.onc.1209874

Genes

BRCA2
BRCA1
RAD51

Provenance

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