Article
The gene encoding proline dehydrogenase modulates sensorimotor gating in mice.
Nature genetics - 1 Apr 1999
Gogos J A, Santha M, Takacs Z, Beck K D, Luine V, Lucas L R, Nadler J V, Karayiorgou M
Abstract excerpt
Hemizygous cryptic deletions of the q11 band of human chromosome 22 have been associated with a number of psychiatric and behavioural phenotypes, including schizophrenia. Here we report the isolation and characterization of PRODH, a human homologue of Drosophila melanogaster sluggish-A (slgA), which encodes proline dehydrogenase responsible for the behavioural phenotype of the slgA mutant. PRODH is localized at...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.