Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.

Cell reports - 4 Oct 2016

Crabtree Gregg W, Park Alan J, Gordon Joshua A, Gogos Joseph A

Abstract excerpt

Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11.2 deletion suggesting a role in disease. Supporting this, elevated L-proline levels have been shown to increase risk for psychotic disorders. Despite the strength of data linking PRODH and L-proline to neuropsychiatric diseases, targets of disease-relevant concentrations of L-proline have not been convincingly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Proline
Share to Central Nervous System
Share to Cytosol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to gamma-Aminobutyric Acid

Share to Glutamate Decarboxylase

Share to Proline Oxidase

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 27705802
DOI: 10.1016/j.celrep.2016.09.029
PMCID: PMC5104186

Genes

PRODH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.PMID 27705802Read ↗

PRODH variants and risk for schizophrenia.Semantic proximity Read ↗

Altered GABAergic Signaling in Brain Disease at Various Stages of LifeSemantic proximity Read ↗

The gene encoding proline dehydrogenase modulates sensorimotor gating in mice.Semantic proximity Read ↗

Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice.Semantic proximity Read ↗

Potential glutamatergic and GABAergic false neurotransmitters in models of excitation-inhibition imbalanceSemantic proximity Read ↗

Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma.Semantic proximity Read ↗

Vitamin D insufficiency and schizophrenia risk: evaluation of hyperprolinemia as a mediator of association.Semantic proximity Read ↗

Increased susceptibility to 4-HNE-induced toxicity and impaired development in a model of ALDH4A1-deficient pediatric epilepsy carrying the S352L variant.Semantic proximity Read ↗

A marker chromosome in psychosis identifies glycine decarboxylase (GLDC) as a novel regulator of neuronal and synaptic function in the hippocampusSemantic proximity Read ↗

GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine productionSemantic proximity Read ↗

Clioquinol improves catalytic activity of PHGDH and shows antiseizure efficacy in patientsSemantic proximity Read ↗

Cortico-Striatal GABAergic and Glutamatergic Dysregulations in Subjects at Ultra-High Risk for Psychosis Investigated with Proton Magnetic Resonance Spectroscopy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.