Article
The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme involved in glutamate biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1993
Hayward D C, Delaney S J, Campbell H D, Ghysen A, Benzer S, Kasprzak A B, Cotsell J N, Young I G, Miklos G L
Abstract excerpt
Certain gene mutations in Drosophila melanogaster cause sluggish motor activity. We have localized the transcription unit of the sluggish-A gene to a 14.7-kb region at the base of the X chromosome and have cloned corresponding cDNAs. The predicted protein product has significant sequence similarity to Saccharomyces cerevisiae proline oxidase (EC 1.5.99.8), a mitochondrial enzyme which catalyzes the first step in...
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