Article
The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme involved in glutamate biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1993
Hayward D C, Delaney S J, Campbell H D, Ghysen A, Benzer S, Kasprzak A B, Cotsell J N, Young I G, Miklos G L
Abstract excerpt
Certain gene mutations in Drosophila melanogaster cause sluggish motor activity. We have localized the transcription unit of the sluggish-A gene to a 14.7-kb region at the base of the X chromosome and have cloned corresponding cDNAs. The predicted protein product has significant sequence similari...
Topics
- Amino Acid Sequence
- Animals
- Chromosome Mapping
- DNA Probes
- Drosophila melanogaster
- Glutamates
- Glutamic Acid
- In Situ Hybridization
- Kinetics
- Male
- Mitochondria
- Molecular Sequence Data
- Motor Activity
- Mutation