Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer.

Carcinogenesis - 1 Dec 1999

Sohn K J, Puchyr M, Salomon R N, Graeme-Cook F, Fung L, Choi S W, Mason J B, Medline A, Kim Y I

Abstract excerpt

Dietary inadequacy of folate enhances and folate supplementation suppresses colorectal carcinogenesis in the dimethylhydrazine rat model. Folate is an essential factor for DNA methylation and the de novo biosynthesis of nucleotides, aberrations of which play important roles in mutagenesis. This study investigated whether the mutational hot spots of the Apc and p53 genes for human colorectal cancer are mutated in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Folic Acid

Share to Genes, APC

Share to Genes, p53

Share to Rats, Inbred F344

Share to Rats, Sprague-Dawley

Source

Identifiers

PMID: 10590231
DOI: 10.1093/carcin/20.12.2345

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer.PMID 10590231Read ↗

Folate, colorectal carcinogenesis, and DNA methylation: Lessons from animal studiesSemantic proximity Read ↗

Frequent mutation of Apc gene in rat colon tumors and mucin-depleted foci, preneoplastic lesions in experimental colon carcinogenesis.Semantic proximity Read ↗

High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.Semantic proximity Read ↗

Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.Semantic proximity Read ↗

Mutational and LOH analyses of p53 alleles in colon tumors induced by 1,2-dimethylhydrazine in F1 hybrid mice.Semantic proximity Read ↗

The relationship between 1,2-dimethylhydrazine dose and the induction of colon tumours: tumour development in female SWR mice does not require a K-ras mutational event.Semantic proximity Read ↗

Dietary folate and APC mutations in sporadic colorectal cancer.Semantic proximity Read ↗

A locus that influences susceptibility to 1, 2-dimethylhydrazine-induced colon tumors maps to the distal end of mouse chromosome 3.Semantic proximity Read ↗

Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon.Semantic proximity Read ↗

Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in ratsSemantic proximity Read ↗

The potent colon carcinogen, 1,2-dimethylhydrazine induces mutations primarily in the colon.Semantic proximity Read ↗

Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.