Article
Microsatellite instability, chemosensitivity and mutant frequency in a series of 1,2-dimethylhydrazine induced murine colon adenocarcinoma models.
International journal of oncology - 1 Sept 1998
Thompson M J, Slack R, Double J A, Bibby M C
Abstract excerpt
Loss of DNA mismatch repair has been described in a number of tumour types such as colorectal adenocarcinoma and leads to microsatellite instability. This may have clinical relevance due to mismatch repair defects altering chemosensitivity towards certain classes of anti-tumour agent. This study...
Topics
- 1,2-Dimethylhydrazine
- Adenocarcinoma
- Animals
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Carcinogens
- Cisplatin
- Colonic Neoplasms
- DNA Repair
- DNA, Neoplasm
- Disease Models, Animal
- Drug Screening Assays, Antitumor
- Humans
- Loss of Heterozygosity
- Mice
- Microsatellite Repeats
- Mutation
- Thioguanine