Article
Mismatch repair-dependent mutagenesis in nondividing cells.
Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2012
Rodriguez Gina P, Romanova Nina V, Bao Gaobin, Rouf N Cynthia, Kow Yoke Wah, Crouse Gray F
Abstract excerpt
Mismatch repair (MMR) is a major DNA repair pathway in cells from all branches of life that removes replication errors in a strand-specific manner, such that mismatched nucleotides are preferentially removed from the newly replicated strand of DNA. Here we demonstrate a role for MMR in helping create new phenotypes in nondividing cells. We show that mispairs in yeast that escape MMR during replication can later...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.