Cellular and molecular mechanisms of asbestos carcinogenicity: implications for biopersistence.

doi:10.1289/ehp.94102s519

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Article

Cellular and molecular mechanisms of asbestos carcinogenicity: implications for biopersistence.

Environmental health perspectives - 1 Oct 1994

Barrett J C

Abstract excerpt

Carcinogenic agents can influence the carcinogenic process either by mutating critical target genes or by increasing the number of cells at risk for mutations. Cytogenetic and molecular studies of asbestos-related cancers indicate that inactivation or loss of multiple tumor suppressor genes occur...

Topics

Asbestos
Carcinogens, Environmental
Cell Division
Genes, Tumor Suppressor
Humans
Lung Neoplasms
Mutation
Time Factors

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