Article
Radiation-induced G1 arrest is not defective in fibroblasts from Li-Fraumeni families without TP53 mutations.
British journal of cancer - 1 Apr 1999
Boyle J M, Greaves M J, Camplejohn R S, Birch J M, Roberts S A, Varley J M
Abstract excerpt
Radiation-induced G1 arrest was studied in four classes of early passage skin fibroblasts comprising 12 normals, 12 heterozygous (mut/wt) TP53 mutation-carriers, two homozygous (mut/-) TP53 mutation-carriers and 16 strains from nine Li-Fraumeni syndrome or Li-Fraumeni-like families in which no TP53 mutation has been found, despite sequencing of all exons, exon-intron boundaries, 3' and 5' untranslated regions and...
Topics
- Alleles
- Colony-Forming Units Assay
- Fibroblasts
- G1 Phase
- Genetic Carrier Screening
- Humans
- Li-Fraumeni Syndrome
- Mutation
- Saccharomyces cerevisiae