Article
Thyroid carcinoma is characterized by genomic instability: evidence from p53 mutations.
Molecular genetics and metabolism - 1 Feb 2001
Shahedian B, Shi Y, Zou M, Farid N R
Abstract excerpt
p53 is a transcription factor with multifaceted regulatory functions in cell cycle progression, DNA repair, and programmed cell death. Inactivating mutations have been described in 50% of human cancers. These mutations appear to be important in tumor progression and response to chemotherapy and radiation treatment and thus clinical outcome. p53 mutations are found in 14% of malignant thyroid tumors and are more...
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