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Article

Wnt signaling mediates regional specification in the vertebrate face.

Development (Cambridge, England) - 1 Sept 2007

Brugmann Samantha A, Goodnough L Henry, Gregorieff Alex, Leucht Philipp, ten Berge Derk, Fuerer Christophe, Clevers Hans, Nusse Roel, Helms Jill A

Abstract excerpt

At early stages of development, the faces of vertebrate embryos look remarkably similar, yet within a very short timeframe they adopt species-specific facial characteristics. What are the mechanisms underlying this regional specification of the vertebrate face? Using transgenic Wnt reporter embryos we found a highly conserved pattern of Wnt responsiveness in the developing mouse face that later corresponded to...

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PMID: 17699607
DOI: 10.1242/dev.005132

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