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Article

LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis.

Genes & development - 15 Nov 2004

Galceran Juan, Sustmann Claudio, Hsu Shu-Chi, Folberth Stephanie, Grosschedl Rudolf

Abstract excerpt

Wnt signaling, which is mediated by LEF1/TCF transcription factors, has been placed upstream of the Notch pathway in vertebrate somitogenesis. Here, we examine the molecular basis for this presumed hierarchy and show that a targeted mutation of Lef1, which abrogates LEF1 function and impairs the activity of coexpressed TCF factors, affects the patterning of somites and the expression of components of the Notch...

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Identifiers

PMID: 15545629
DOI: 10.1101/gad.1249504
PMCID: PMC528889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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