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Article

Transcriptional regulation of Th2 cell differentiation

12 Jan 2010

Abstract excerpt

CD4 T helper 2 (Th2) cells have critical functions in immune responses against extracellular parasites and are involved in asthma and other allergic diseases. The differentiation of naïve CD4 T cells into Th2 cells is initiated from T-cell receptor and cytokine-mediated signaling followed by upregulation of GATA3 and activation of signal transducer and activator of transcription 5 (STAT5), two indispensable...

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Identifiers

PMID: 20065998
DOI: 10.1038/icb.2009.114

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