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Article

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

Science (New York, N.Y.) - 8 Jun 2001

Mullen A C, High F A, Hutchins A S, Lee H W, Villarino A V, Livingston D M, Kung A L, Cereb N, Yao T P, Yang S Y, Reiner S L

Abstract excerpt

How cytokines control differentiation of helper T (TH) cells is controversial. We show that T-bet, without apparent assistance from interleukin 12 (IL-12)/STAT4, specifies TH1 effector fate by targeting chromatin remodeling to individual interferon-gamma (IFN-gamma) alleles and by inducing IL-12...

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Source

Identifiers

PMID: 11397944
DOI: 10.1126/science.1059835

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11397944-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.PMID 11397944Read ↗

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