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Article

Generation of transmissible hepatitis C virions from a molecular clone in chimpanzees.

Virology - 30 Mar 1999

Hong Z, Beaudet-Miller M, Lanford R E, Guerra B, Wright-Minogue J, Skelton A, Baroudy B M, Reyes G R, Lau J Y

Abstract excerpt

Multiple alignments of hepatitis C virus (HCV) polyproteins from six different genotypes identified a total of 22 nonconsensus mutations in a clone derived from the Hutchinson (H77) isolate. These mutations, collectively, may have contributed to the failure in generating a "functionally correct" or "infectious" clone in earlier attempts. A consensus clone was constructed after systematic repair of these...

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PMID: 10087224
DOI: 10.1006/viro.1999.9603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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