Article
Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo.
Virology - 25 Apr 1998
Yanagi M, St Claire M, Shapiro M, Emerson S U, Purcell R H, Bukh J
Abstract excerpt
We constructed a chimeric cDNA clone of hepatitis C virus (HCV) that is infectious. The chimeric genome encodes the polyprotein of a genotype 1b strain (HC-J4) of HCV and replicates via 5' and 3' untranslated regions of a genotype 1a strain. The infectivity of three full-length cDNA clones was te...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Consensus Sequence
- DNA, Complementary
- DNA, Viral
- Genotype
- Hepacivirus
- Hepatitis C
- Humans
- Molecular Sequence Data
- Open Reading Frames
- Pan troglodytes
- RNA, Viral
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid