Infectious cDNA clone of the hepatitis C virus genotype 1 prototype sequence.

doi:10.1099/0022-1317-82-6-1291

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Article

Infectious cDNA clone of the hepatitis C virus genotype 1 prototype sequence.

The Journal of general virology - 1 Jun 2001

Lanford Robert E, Lee Helen, Chavez Deborah, Guerra Bernadette, Brasky Kathleen M

Abstract excerpt

A full-length cDNA clone of the hepatitis C virus (HCV) genotype 1 prototype (subtype 1a) sequence was constructed. Synthetic RNA produced from the initial cDNA clone was not infectious following intrahepatic inoculation of a chimpanzee. A consensus clone was prepared by comparison with multiple full-length HCV sequences of genotypes 1, 2 and 3. A total of 11 non-consensus amino acid residues were altered by...

Topics

Animals
Cloning, Molecular
Consensus Sequence
DNA, Complementary
DNA, Recombinant
Genotype
Hepacivirus
Hepatitis C
Mutation
Pan troglodytes
RNA, Viral

Source

Open in PubMed

Identifiers

PMID: 11369872
DOI: 10.1099/0022-1317-82-6-1291

Provenance

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