Article
In vivo study of the HC-TN strain of hepatitis C virus recovered from a patient with fulminant hepatitis: RNA transcripts of a molecular clone (pHC-TN) are infectious in chimpanzees but not in Huh7.5 cells.
Journal of virology - 1 Jul 2007
Sakai Akito, Takikawa Shingo, Thimme Robert, Meunier Jean-Christophe, Spangenberg Hans Christian, Govindarajan Sugantha, Farci Patrizia, Emerson Suzanne U, Chisari Francis V, Purcell Robert H, Bukh Jens
Abstract excerpt
Both viral and host factors are thought to influence the pathogenesis of hepatitis C virus (HCV) infection. We studied strain HC-TN (genotype 1a), which caused fulminant hepatic failure in a patient and, subsequently, severe hepatitis in a chimpanzee (CH1422), to analyze the relationship between...
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