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Article

An infectious molecular clone of a Japanese genotype 1b hepatitis C virus.

Hepatology (Baltimore, Md.) - 1 Jul 1999

Beard M R, Abell G, Honda M, Carroll A, Gartland M, Clarke B, Suzuki K, Lanford R, Sangar D V, Lemon S M

Abstract excerpt

We describe an infectious molecular clone of a Japanese genotype 1b strain of hepatitis C virus (HCV-N). The molecularly cloned sequence of HCV-N was compared with alignments of other HCV sequences, leading to the identification of 15 unique, nonconservative amino acid substitutions within the HCV-N open reading frame (ORF). These were repaired to the consensus genotype 1b residue, and the infectivity of RNA...

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PMID: 10385673
DOI: 10.1002/hep.510300137

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