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Article

Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies.

Journal of virology - 1 May 2010

Gottwein Judith M, Scheel Troels K H, Callendret Benoit, Li Yi-Ping, Eccleston Heather B, Engle Ronald E, Govindarajan Sugantha, Satterfield William, Purcell Robert H, Walker Christopher M, Bukh Jens

Abstract excerpt

Previously, RNA transcripts of cDNA clones of hepatitis C virus (HCV) genotypes 1a (strains H77, HCV-1, and HC-TN), 1b (HC-J4, Con1, and HCV-N), and 2a (HC-J6 and JFH1) were found to be infectious in chimpanzees. However, only JFH1 was infectious in human hepatoma Huh7 cells. We performed genetic analysis of HCV genotype 3a (strain S52) and 4a (strain ED43) prototype strains and generated full-length consensus...

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Identifiers

PMID: 20200247
DOI: 10.1128/JVI.02667-09
PMCID: PMC2863810

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