Article
A hepatitis A virus deletion mutant which lacks the first pyrimidine-rich tract of the 5' nontranslated RNA remains virulent in primates after direct intrahepatic nucleic acid transfection.
Journal of virology - 1 Oct 1995
Shaffer D R, Emerson S U, Murphy P C, Govindarajan S, Lemon S M
Abstract excerpt
Cell culture-adapted variants of hepatitis A virus (HAV) in which the first pyrimidine-rich tract (pY1; nucleotides 99 to 138) of the 5' nontranslated region has been deleted (delta 96-137 or delta 96-139) replicate as well as parental virus in cultured cells (D.R. Shaffer, E.A. Brown, and S.M. L...
Topics
- Animals
- Base Sequence
- Cell Line
- Cells, Cultured
- DNA Primers
- Fetus
- Genetic Variation
- Hepatovirus
- Kidney
- Macaca mulatta
- Molecular Sequence Data
- Nucleic Acid Conformation
- Point Mutation
- Polymerase Chain Reaction