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Protein kinase Cα: disease regulator and therapeutic target

7 Dec 2009

Abstract excerpt

Protein kinase Calpha (PKCalpha) is a member of the AGC (which includes PKD, PKG and PKC) family of serine/threonine protein kinases that is widely expressed in mammalian tissues. It is closely related in structure, function and regulation to other members of the protein kinase C family, but has specific functions within the tissues in which it is expressed. There is substantial recent evidence, from gene...

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PMID: 19969380
DOI: 10.1016/j.tips.2009.10.006

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