Article
Protein kinase D is a downstream target of protein kinase Ctheta.
Biochemical and biophysical research communications - 1 Mar 2002
Yuan Jingzhen, Bae David, Cantrell Doreen, Nel Andre E, Rozengurt Enrique
Abstract excerpt
Protein kinase D (PKD/PKCmu immunoprecipitated from either COS-7 cells or Jurkat T lymphocytes transiently transfected with a constitutively active mutant of PKCtheta AE (PKCthetaAE) exhibited a marked increase in basal activity. In contrast, coexpression of constitutively active mutant of PKCzeta does not induce PKD activation in both types of cells. PKCthetaAE does not induce kinase activity in immunocomplexes...
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