Article
Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides.
Blood - 23 Jul 2015
McGirt Laura Y, Jia Peilin, Baerenwald Devin A, Duszynski Robert J, Dahlman Kimberly B, Zic John A, Zwerner Jeffrey P, Hucks Donald, Dave Utpal, Zhao Zhongming, Eischen Christine M
Abstract excerpt
The pathogenesis of mycosis fungoides (MF), the most common cutaneous T-cell lymphoma (CTCL), is unknown. Although genetic alterations have been identified, none are considered consistently causative in MF. To identify potential drivers of MF, we performed whole-genome sequencing of MF tumors and matched normal skin. Targeted ultra-deep sequencing of MF samples and exome sequencing of CTCL cell lines were also...
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